Compare Adderall vs Dexedrine vs Focalin XR vs Intuniv ADHD Medications

Overview:

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Basic Information
Generic Name	Amphetamine And Dextroamphetamine	Dextroamphetamine	Dexmethylphenidate	Guanfacine
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Class	Cns Stimulants	Cns Stimulants	Cns Stimulants	Antiadrenergic Agents, Centrally Acting
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Prescription Generic Available	Yes	Yes	No	No
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Pregnancy cat.	C(us)	B3(au) C(us)	C(us)	B(us)
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Approved Age	3 And Older	6 And Older	6 And Older	6 And Older
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Legal Status	Schedule I (ca) Schedule Ii (us)	Controlled (s8)(au) Schedule I(ca) Class B(uk) Schedule Ii(us)	Schedule Ii (us)
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WADA Category	S6 - Stimulants
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Dependence Liability	High	High	High
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Excretion	Urinary	Urinary	Urinary	Renal
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Possible Side Effects	Some Loss Of Appetite, Weight Loss, Sleep Problems, Irritability, Tics.	Some Loss Of Appetite, Weight Loss, Sleep Problems, Irritability, Tics.	Some Loss Of Appetite, Weight Loss, Dry Mouth, Indigestion, Headaches, Anxiety, Throat Pain, Indigestion, Stomach Cramps	Sleepiness, Headache, Fatigue, Abdominal Pain. Rarely, Intuniv Can Cause Low Blood Pressure And Heart Rhythm Changes.
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Dosage, Usage and Forms
Routes (of administration)	(medical) Oral, Insufflated, Intravenous	Oral, Insufflation, Rectal, Sublingual	Oral	Oral
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Dosage	5–30 Mg Bid Or 5–60 Mg Q Am		6-17: 5 Mg Q Am–30 Mg Q Am; Adults: 10 Mg Q Am-40 Mg Q Am	1–4 Mg Daily (do Not Increase Faster Than 1 Mg/wk)
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Maximum daily dose	60 mg		40 mg	4 mg
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Duration	Intermediate-acting	Short-acting	Long-acting	Long-acting
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Duration - time	4-8 H	4-6 H	8-12 H	24 h
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Chemical Data
Molecular mass (g/mol)	135.21 G/mol	135.21 G/mol	269.77 G/mol	246.093 G/mol
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Half Life	10 Hours	4-6 Hrs	2-4.5 Hours	14.8-18.3 Hours
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Formula	C9h13n	C9h13n	C14h19no2•hcl	C9h9cl2n3o
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Bioavailability	Nasal 75%; Rectal 95-99%; Intravenous 100%	75% (oral)	30 %	80-100%
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Protein binding	15-40%	15 %	12-15%	70 %
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Metabolism	Hepatic	Hepatic	Hepatic	Hepatic
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