Compare:
| Concerta | Focalin XR | Vyvanse | ||
| Basic Information | ||||
| Generic Name | Methylphenidate | Dexmethylphenidate | Lisdexamfetamine | |
| Class | Cns Stimulants | Cns Stimulants | Cns Stimulants | |
| Prescription Generic Available | Yes | No | No | |
| Pregnancy cat. | C(us) | C(us) | C(us) | |
| Approved Age | 6 And Older | 6 And Older | 6 And Older | |
| Legal Status | Schedule Ii (us) | Schedule Ii (us) | Pharmacist Only (au) Pom (uk) Schedule Ii (us) | |
| WADA Category | S6 - Stimulants | |||
| Dependence Liability | High | High | ||
| Excretion | Urinary | Urinary | Renal: ~2% | |
| Possible Side Effects | Some Loss Of Appetite, Weight Loss, Sleep Problems, Irritability, Tics. | Some Loss Of Appetite, Weight Loss, Dry Mouth, Indigestion, Headaches, Anxiety, Throat Pain, Indigestion, Stomach Cramps | Some Loss Of Appetite, Weight Loss, Sleep Problems, Irritability, Tics. | |
| Dosage, Usage and Forms | ||||
| Routes (of administration) | Oral | Oral | Oral | |
| Dosage | 18 Mg Q Am–72 Mg Q Am (if 12+ Y.o.) | 6-17: 5 Mg Q Am–30 Mg Q Am; Adults: 10 Mg Q Am-40 Mg Q Am | 30 Mg Q Am–70 Mg Q Am | |
| Maximum daily dose | 72 mg |
40 mg |
70 mg |
|
| Duration | Long-acting | Long-acting | Long-acting | |
| Duration - time | 10-16 H | 8-12 H | 8-12 H | |
| Chemical Data | ||||
| Molecular mass (g/mol) | 269.77 G/mol | 269.77 G/mol | 263.378 G/mol | |
| Half Life | 3-5 Hours | 2-4.5 Hours | < 1 Hour (prodrug Molecule), 12-13 Hours (d-amphetamine) | |
| Formula | C14h19no2•hcl | C14h19no2•hcl | C15h25n3o | |
| Bioavailability | 11-52% |
30 % |
28 % |
|
| Protein binding | 15 % |
12-15% |
||
| Metabolism | Hepatic | Hepatic | Gastro-intestinal (initial); Hepatic (extensively Cyp2d6) After Conversion To D-amphetamine | |