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Compare Concerta vs Focalin XR vs Metadate ER vs Ritalin LA vs Vyvanse ADHD Medications

Overview:

 
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Basic Information
 
Generic Name
Methylphenidate Dexmethylphenidate Methylphenidate Methylphenidate Lisdexamfetamine
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Class
Cns Stimulants Cns Stimulants Cns Stimulants Cns Stimulants Cns Stimulants
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Prescription Generic Available
Yes No Yes Yes No
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Pregnancy cat.
C(us) C(us) C(us) C(us) C(us)
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Approved Age
6 And Older 6 And Older 6 And Older 6 And Older 6 And Older
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Legal Status
Schedule Ii (us) Schedule Ii (us) Schedule Ii (us) Schedule Ii (us) Pharmacist Only (au) Pom (uk) Schedule Ii (us)
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WADA Category
S6 - Stimulants S6 - Stimulants S6 - Stimulants
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Dependence Liability
High High Moderate High
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Excretion
Urinary Urinary Urinary Urinary Renal: ~2%
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Possible Side Effects
Some Loss Of Appetite, Weight Loss, Sleep Problems, Irritability, Tics. Some Loss Of Appetite, Weight Loss, Dry Mouth, Indigestion, Headaches, Anxiety, Throat Pain, Indigestion, Stomach Cramps Some Loss Of Appetite, Weight Loss, Sleep Problems, Irritability, Tics. Some Loss Of Appetite, Weight Loss, Sleep Problems, Irritability, Tics. Some Loss Of Appetite, Weight Loss, Sleep Problems, Irritability, Tics.
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Dosage, Usage and Forms
 
Routes (of administration)
Oral Oral Oral Oral, Transdermal Oral
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Dosage
18 Mg Q Am–72 Mg Q Am (if 12+ Y.o.) 6-17: 5 Mg Q Am–30 Mg Q Am; Adults: 10 Mg Q Am-40 Mg Q Am 10 Mg Q Am–30 Bid (max 60mg/day) 20–60 Mg Q Am 30 Mg Q Am–70 Mg Q Am
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Maximum daily dose
72 mg
40 mg
60 mg
60 mg
70 mg
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Duration
Long-acting Long-acting Intermediate-acting Long-acting Long-acting
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Duration - time
10-16 H 8-12 H 6-8 H 8-12 H 8-12 H
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Chemical Data
 
Molecular mass (g/mol)
269.77 G/mol 269.77 G/mol 269.77 G/mol 269.77 G/mol 263.378 G/mol
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Half Life
3-5 Hours 2-4.5 Hours
3.4 Hours
3-5 Hours < 1 Hour (prodrug Molecule), 12-13 Hours (d-amphetamine)
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Formula
C14h19no2•hcl C14h19no2•hcl C14h19no2•hcl C14h19no2•hcl C15h25n3o
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Bioavailability
11-52%
30 %
30 %
30 %
28 %
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Protein binding
15 %
12-15%
15 %
10%-33%
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Metabolism
Hepatic Hepatic Hepatic Hepatic Gastro-intestinal (initial); Hepatic (extensively Cyp2d6) After Conversion To D-amphetamine
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