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Compare Adderall XR vs Focalin XR vs Methylin ER vs Strattera vs Vyvanse ADHD Medications
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| Basic Information | |||||
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Generic Name
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Amphetamine And Dextroamphetamine | Dexmethylphenidate | Methylphenidate | Atomoxetine | Lisdexamfetamine |
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Class
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Cns Stimulants | Cns Stimulants | Cns Stimulants | Cns Stimulants | Cns Stimulants |
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Prescription Generic Available
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Yes | No | Yes | No | No |
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Pregnancy cat.
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C(us) | C(us) | C(us) | B3(au) C(us) | C(us) |
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Approved Age
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3 And Older | 6 And Older | 6 And Older | 6 And Older | 6 And Older |
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Legal Status
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Schedule Ii (us) | Schedule Ii (us) | Schedule Ii (us) | Pharmacist Only (au) Pom (uk) Schedule Ii (us) | |
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WADA Category
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S6 - Stimulants | S6 - Stimulants | |||
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Dependence Liability
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High | High | Moderate | ||
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Excretion
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Urinary | Urinary | Urinary | Renal (>80%) And Fecal ( | Renal: ~2% |
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Possible Side Effects
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Some Loss Of Appetite, Weight Loss, Sleep Problems, Irritability, Tics. | Some Loss Of Appetite, Weight Loss, Dry Mouth, Indigestion, Headaches, Anxiety, Throat Pain, Indigestion, Stomach Cramps | Some Loss Of Appetite, Weight Loss, Sleep Problems, Irritability, Tics. | Sleep Problems, Anxiety, Fatigue, Upset Stomach, Dizziness, Dry Mouth. Rarely, Liver Damage | Some Loss Of Appetite, Weight Loss, Sleep Problems, Irritability, Tics. |
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| Dosage, Usage and Forms | |||||
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Routes (of administration)
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(medical) Oral, Insufflated, Intravenous | Oral | Oral | Oral | Oral |
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Dosage
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5 Mg Q Am–40 Mg Q Am | 6-17: 5 Mg Q Am–30 Mg Q Am; Adults: 10 Mg Q Am-40 Mg Q Am | 20 Mg Q Am–60 Mg Q Am | 30 Mg Q Am–70 Mg Q Am | |
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Maximum daily dose
|
40 mg |
40 mg |
60 mg |
70 mg |
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Duration
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Long-acting | Long-acting | Intermediate-acting | Long-acting | Long-acting |
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Duration - time
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10-14 H | 8-12 H | 4-8 H | 24 h |
8-12 H |
| Chemical Data | |||||
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Molecular mass (g/mol)
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135.21 G/mol | 269.77 G/mol | 269.77 G/mol | 255.36 G/mol 291.81 G/mol (hydrochloride) | 263.378 G/mol |
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Half Life
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10 Hours |
2-4.5 Hours | 5-8 Hours | 5 Hours |
< 1 Hour (prodrug Molecule), 12-13 Hours (d-amphetamine) |
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Formula
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C9h13n | C14h19no2•hcl | C14h19no2•hcl | C17h21no | C15h25n3o |
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Bioavailability
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Nasal 75%; Rectal 95-99%; Intravenous 100% | 30 % |
30 % |
63-94% |
28 % |
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Protein binding
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15 % |
12-15% |
16 % |
40 % |
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Metabolism
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Hepatic | Hepatic | Hepatic | Hepatic, Via Cyp2d6 | Gastro-intestinal (initial); Hepatic (extensively Cyp2d6) After Conversion To D-amphetamine |
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