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Compare Adderall XR vs Concerta vs Dextrostat vs Focalin vs Intuniv vs Strattera vs Vyvanse ADHD Medications

Overview:

 
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Basic Information
 
Generic Name
Amphetamine And Dextroamphetamine Methylphenidate Dextroamphetamine Dexmethylphenidate Guanfacine Atomoxetine Lisdexamfetamine
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Class
Cns Stimulants Cns Stimulants Cns Stimulants Cns Stimulants Antiadrenergic Agents, Centrally Acting Cns Stimulants Cns Stimulants
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Prescription Generic Available
Yes Yes Yes Yes No No No
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Pregnancy cat.
C(us) C(us) C(us) C(us) B(us) B3(au) C(us) C(us)
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Approved Age
3 And Older 6 And Older 3 And Older 6 And Older 6 And Older 6 And Older 6 And Older
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Legal Status
Schedule Ii (us) Schedule Ii (us) Schedule Ii (us) Schedule Ii (us) Pharmacist Only (au) Pom (uk) Schedule Ii (us)
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WADA Category
S6 - Stimulants S6 - Stimulants
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Dependence Liability
High High High High
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Excretion
Urinary Urinary Urinary Renal Renal Renal (>80%) And Fecal ( Renal: ~2%
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Possible Side Effects
Some Loss Of Appetite, Weight Loss, Sleep Problems, Irritability, Tics. Some Loss Of Appetite, Weight Loss, Sleep Problems, Irritability, Tics. Some Loss Of Appetite, Weight Loss, Sleep Problems, Irritability, Tics. Some Loss Of Appetite, Weight Loss, Sleep Problems, Irritability, Tics. Sleepiness, Headache, Fatigue, Abdominal Pain. Rarely, Intuniv Can Cause Low Blood Pressure And Heart Rhythm Changes. Sleep Problems, Anxiety, Fatigue, Upset Stomach, Dizziness, Dry Mouth. Rarely, Liver Damage Some Loss Of Appetite, Weight Loss, Sleep Problems, Irritability, Tics.
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Dosage, Usage and Forms
 
Routes (of administration)
(medical) Oral, Insufflated, Intravenous Oral Oral Oral Oral Oral Oral
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Dosage
5 Mg Q Am–40 Mg Q Am 18 Mg Q Am–72 Mg Q Am (if 12+ Y.o.) 3-5: 2.5mg Qam–20 Mg Bid; 5- 16: 5 Mg Q Am–20 Mg Bid 2.5 Mg Bid–10 Mg Bid 1–4 Mg Daily (do Not Increase Faster Than 1 Mg/wk) 30 Mg Q Am–70 Mg Q Am
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Maximum daily dose
40 mg
72 mg
20 mg
10 mg
4 mg
70 mg
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Duration
Long-acting Long-acting Short-acting Short-acting Long-acting Long-acting Long-acting
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Duration - time
10-14 H 10-16 H 3-5 H 3-4 H
24 h
24 h
8-12 H
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Chemical Data
 
Molecular mass (g/mol)
135.21 G/mol 269.77 G/mol 135.206 G/mol 233.31 G/mol 246.093 G/mol 255.36 G/mol 291.81 G/mol (hydrochloride) 263.378 G/mol
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Half Life
10 Hours
3-5 Hours
10 Hours
4 Hours
14.8-18.3 Hours
5 Hours
< 1 Hour (prodrug Molecule), 12-13 Hours (d-amphetamine)
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Formula
C9h13n C14h19no2•hcl (c9h13n)2•h2so4 C14h19no2 C9h9cl2n3o C17h21no C15h25n3o
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Bioavailability
Nasal 75%; Rectal 95-99%; Intravenous 100%
11-52%
22-25%
80-100%
63-94%
28 %
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Protein binding
15 %
15 %
12-15%
70 %
40 %
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Metabolism
Hepatic Hepatic Hepatic Hepatic Hepatic Hepatic, Via Cyp2d6 Gastro-intestinal (initial); Hepatic (extensively Cyp2d6) After Conversion To D-amphetamine
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